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Nakagawa, M., Yamaguchi, T., Ueda, H., Shiraishi, N., Komiyama, S., Akiyama, S., Ogata, J. and Kuwano, M. (1985) Potentiation by Vitamin A of the Action of Anticancer Agents against Murine Tumors. Japanese Journal of Cancer Research, 76, 887-888.

has been cited by the following article:

• TITLE: Cardiac Manifestations with Chemotherapeutic Agents: 5 Fluorouracil-Induced Coronary Artery Vasospasm

  AUTHORS: Vignendra Ariyarajah, Mohamed S. Hameed, Mohamed Firdaus M. Mydeen, Guillermo J. Crespo

  KEYWORDS: 5-Fluorouracil, Chemotherapeutic Agent, Cardiotoxicity, Vasospasm

  JOURNAL NAME: World Journal of Cardiovascular Surgery, Vol.13 No.8, August 31, 2023

  ABSTRACT: 5-fluorouracil (5-FU) is a fluorinated, pyrimidine analog, antineoplastic agent that is used in the treatment of several solid organ cancers. Cardiotoxicity is uncommon but life-threatening manifestations such as myocardial infarction may manifest owing to 5-FU-induced coronary artery spasm. Administering smaller doses of the drug, more frequently than not, decreases the risk of cardiotoxicity compared to large doses or with continuous infusions. We present a case of ST-segment elevation in a patient without known coronary artery disease who had presented following continuous 5-FU infusion. Coronary angiogram confirmed absence of coronary artery disease and intravenous calcium channel blockers administration was commensurate with the patient’s improvement in symptoms. We discuss the literature on 5-FU and its association with coronary artery spasm, and also briefly review chemotherapy-induced cardiotoxicities to help better prepare internists and other primary health care providers to face similar challenges, particularly of the uncommon but potentially life-threatening manifestations.