TITLE:
Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
AUTHORS:
Emeline Sorelle Mefouegang, Claudelle Sybilline Anensong Djadock, Golngar Djimassingar, Gabriel Tchuente Kamsu, Donald Raoul Tchuifon Tchuifon, Alain Charly Tagne Kuate, Dirk Bockfeld, Jean Ngoune
KEYWORDS:
Cobalt, Acylpyrazolone, X-Ray Diffraction, Antimicrobial Activity, 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
JOURNAL NAME:
Journal of Materials Science and Chemical Engineering,
Vol.11 No.8,
August
31,
2023
ABSTRACT: New cobalt(II) complex, [Co(O2C15H11N2S)2(OH2)2]∙2H2O (1∙2H2O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)2∙6H2O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H2O. Compound 1∙2H2O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H2O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H2O displayed moderate activity (10 ∙2H2O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).