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Mansouri, M.A., Sacré, P.Y., Coïc, L., Bleye, C.D., Dumont, E., Bouklouze, A., Hubert, P., Marini, R.D. and Ziemons, E. (2020) Quantitation of Active Pharmaceutical Ingredient through the Packaging Using Raman Handheld Spectrophotometers: A Comparison Study. Talanta, 207, Article ID: 120306.
https://doi.org/10.1016/j.talanta.2019.120306

has been cited by the following article:

• TITLE: Vibrational Spectroscopy of Pain Relievers: Traditional and Remote Raman Techniques

  AUTHORS: Aschalew Kassu, Damoni Robinson

  KEYWORDS: Raman Spectroscopy, Acetaminophen, Aspirin, Standoff Raman, Vibrational Spectroscopy, Pain Relievers

  JOURNAL NAME: Journal of Analytical Sciences, Methods and Instrumentation, Vol.13 No.3, August 31, 2023

  ABSTRACT: The application of vibrational spectroscopy in the pharmaceutical industry is widely investigated, from the quality assurance of the product during the production process control to the final products’ quality control and the authentication of products on the markets. This study focuses on non-contact and noninvasive detection and identification of pain-relievers at 1-5 meters standoff distances. The specimens analyzed include standard laboratory-grade active ingredients and commercially available pain relievers in powder, solid and liquid forms. All the remote measurements captured revealed the Raman signatures of the specimens, with varying peak intensities. To correlate the band intensities captured with the standoff distances between the laser source and the specimens, the intensity ratios of the two prominent peaks of the laboratory grade reference active ingredient (1607 and 1319 cm-1) normalized with 1319 cm-1 are used. The results of the study suggest the viability of standoff Raman spectroscopy for routine monitoring and identification of pharma-ceuticals, including counterfeit pain relievers.