TITLE:
Analysis of Human Papillomavirus Infection in Cervical Exfoliated Cells
AUTHORS:
Yuan Xu, Qi Wen, Zheng Zhao, Ke Zhang, Shuying Li
KEYWORDS:
Cervical Exfoliating Cells, Human Papillomavirus, Infection, Cervical Lesions, Clinicopathological Features
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.11 No.8,
August
30,
2023
ABSTRACT: To screen patients with early cervical lesions by analyzing the infection of high-risk Human papillomavirus (HR-HPV). Research Methods: The cervical exfoliated cell specimens and their clinical data were collected. The HPV infection types of the collected specimens were detected by fluorescence quantitative PCR, and the correlation between HPV infection and clinicopathological features was analyzed statistically. Results: 725 cases were HR-HPV positive from 2605 cases, including 15 high-risk types of HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68. Different histological types ranged from NILM to HSIL, and the positive rate of HPV showed an increasing trend with the aggravation of cervical lesions. Conclusion: The positive rate of 15 high-risk HPV types in the collected specimens was 27.8%. Patients with early cervical lesions could be screened for 15 high-risk HPV infection types.