Article citationsMore>>

Sander, L.C., Bedner, M., Tims, M.C., Yen, J.H., Duewer, D.L., Porter, B., Christopher, S.J., Day, R.D., Long, S.E., Molloy, J.L., Murphy, K.E., et al. (2012) Development and Certification of Green Tea-Containing Standard Reference Materials. Analytical and Bioanalytical Chemistry, 402, 473-487.
https://doi.org/10.1007/s00216-011-5472-7

has been cited by the following article:

• TITLE: Development of a Certified Reference Material from Caffeine Solution for Assuring the Quality of Food and Drug Measurements

  AUTHORS: Adel B. Shehata, Abdulrahman R. AlAskar, Mohammed A. AlRasheed, Abdulrahman M. AlZahrany, Fahd A. AlKharraa, Sowailem A. AlSowailem

  KEYWORDS: Caffeine, Reference Material, Homogeneity, Stability, Characterization, Certification

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.13 No.3, August 29, 2023

  ABSTRACT: Caffeine intake by pregnant women, adults and children can be harmful to the health of all particularly fetuses if the intake exceeds the permissible limits. Therefore, it is of fundamental importance to measure its concentration accurately using certified reference materials (CRMs). In the literature, no scientific details are published about the certification of caffeine standard solutions, and therefore, the present article covers this gap. A batch of caffeine solution was prepared in concentration of 1000 mg/kg and bottled. Homogeneity and stability of the candidate reference material were assessed by HPLC-UV and the results showed that the material is homogenous and stable enough. Characterization of the caffeine reference material was performed by HPLC-UV, LC-MS/MS and UV-VIS-NIR spectrophotometer in three different days and the characterization uncertainty was estimated in accordance with the requirements of ISO GUM. The certified value (999.86 ± 8.54 mg/kg) was derived as a weighted mean from the gravimetry and the three characterization methods and the certified uncertainty was calculated according to ISO Guide 35. The produced CRM is of strong interest to the food and drug analytical laboratories for the validity and credibility of their caffeine measurement results.