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Ciccone, M., Agostinelli, C., Rigolin, G.M., Piccaluga, P.P., Cavazzini, F., Righi, S., Sista, M.T., Sofritti, O., Rizzotto, L., Sabattini, E., Fioritoni, G., Falorio, S., Stelitano, C., Olivieri, A., Attolico, I., Brugiatelli, M., Zinzani, P.L., Saccenti, E., Capello, D., Negrini, M., Cuneo, A. and Pileri, S. (2012) Proliferation Centers in Chronic Lymphocytic Leukemia: Correlation with Cytogenetic and Clinicobiological Features in Consecutive Patients Analyzed on Tissue Microarrays. Leukemia, 26, 499-508.
https://doi.org/10.1038/leu.2011.247

has been cited by the following article:

• TITLE: A Rare Entity of Accelerated Chronic Lymphocytic Leukemia: A Report of Two Cases and Review of Literature

  AUTHORS: Zahra Kmira, Ben Yahya Noura, Chembah Wafa, Ben Sayed Nesrine, Chiba Dorra, Bouteraa Walid, Zaier Monia, Ben Youssef Yosra, Haifa Regaieg, Khelif Abderrahim

  KEYWORDS: Accelerated Chronic Lymphocytic Leukemia, Richter Transformation, Prognosis, Treatment

  JOURNAL NAME: Health, Vol.15 No.8, August 22, 2023

  ABSTRACT: Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases of chronic lymphoid leukemia (CLL). Moreover, it is most likely an under diagnosed entity due to its rarity and the non-standardized practice of lymph node biopsy in CLL. Purpose: The aims of our work are to establish the diagnosis of A-CLL and to study the prognosis and treatment of this rare entity. Method: here, we report the clinical presentation and the follow up of two cases of A-CLL. Results: Distinguishing Richter transformation (RT) from A-CLL is important as it may result in a major change in disease management. The prognosis of A-CLL is intermediate between CLL and RT. The prognosis is mainly poor due to a predominance of poor prognostic markers including an increasing number of p53-positive cases. Conclusion: To this date, no prospective study has been led to define the best treatment for A-CLL. The shorter survival of A-CLL when compared to typical CLL implies the need of a more aggressive treatment.