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Faderl, S. and Kantarjian, H.M. (2013) Clinical Manifestations and Treatment of Acute Myeloid Leukemia. In: Hoffman, R., Benz Jr., E.J., Silberstein, L.E., Heslop, H.E., Weitz, J.I. and Anastasi, J., Eds., Hematology: Basic Principles and Practice, 6th Edition, Elsevier Saunders, Philadelphia.

has been cited by the following article:

• TITLE: Prognostic Value of Neutrophil to Lymphocyte Ratio in Acute Myeloid Leukemia

  AUTHORS: Seda Yilmaz, Özcan Çeneli

  KEYWORDS: Acute Myeloid Leukemia, Neutrophil to Lymphocyte Ratio, Prognosis, Survival

  JOURNAL NAME: Open Journal of Internal Medicine, Vol.13 No.3, July 28, 2023

  ABSTRACT: Objective: Acute myeloid leukemia (AML) is a heterogeneous, hematologic malignancy at which short survival may be seen. Our study aims to evaluate the effect of the neutrophil-to-lymphocyte ratio (NLR) on the course of the disease, response to therapy, and overall survival (OS). Materials and Methods: A total of 124 patients followed-up with the diagnosis of AML from 2016 to 2019 were retrospectively examined. Results: 69 of the cases (55.6%) were men and 55 (44.3%) were women. The average age at the time of diagnosis was 53.44 ± 30.3 years old. We determined the NLR as median 0.46 (0.16 - 1.1). In AML, 69 patients were responsive to the induction regimen (57.9%) while 46 patients were unresponsive (37.8%). 5 patients died before completing the regimen. D-dimer was found to be higher and fibrinogen was found to be lower in the responsive group. Lower OS was observed in cases of >60 years of age, male gender, non-APL AML, high NLR, and recurrence at diagnosis. Recurrences were detected in 23 patients (18.5%) and the median time to the recurrence was 416 (236 - 639) days. Fibrinogen level and the bone marrow blast ratio at the time of application were determined to be associated with recurrence. The median follow-up time was 856 (143 - 1276) days. Final condition analysis reveals that 74 patients (59.6%) are alive. Conclusion: We determined in our study that the NLR is effective on survival. Medical literature on this subject is scanty and prospective studies with large patient groups are needed.