TITLE:
Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy
AUTHORS:
Mamadou Moustapha Diop, Aissata Barry, Ouo Ouo Kolié, Emanuel Camara, Mohamed Lamine Diallo, Kaba Bangoura, Mamadou Aliou Doukouré, Pé Neabel Beimy, Dienab Diallo, Moustapha Kouyate, Mohamed Lamine Kaba
KEYWORDS:
GFR, Child, Cancer, Chemotherapy
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.13 No.4,
July
28,
2023
ABSTRACT: Introduction: Glomerular filtration is an
important elimination pathway for many types of chemotherapy. Accurate
estimation of glomerular filtration is essential in the management of children
with cancer. Methodology: This was a prospective cross-sectional study
of the descriptive type extending over a period of 6 months from July 01 to
December 31, 2021 on all children
with cancer followed in the pediatric hemato-oncology unit of the HND with a
renal, blood and urinary assessment associated with the GFR calculated by the
SCHWARTZ formula during the study period. Results: During the study
period, we registered 41 new cases of cancer in the pediatric oncology unit.
The age group of 0 - 5 years was the most represented, i.e. 65.85% and the average age was 5.6 ± 4 years. The most cited
clinical signs were fever ie 56.10% followed by abdominal pain 34.15% and
anemia 26.83%. The most represented diagnosis was Burkitt’s Lymphoma, i.e. 26.83% followed by Retinoblastoma
24.39%. Mean serum creatinine was 70.65 ± 68.93 μmol/L. In our series, patients
whose normal glomerular filtration rate were more represented, i.e. 70.73% and 29.27% had an abnormal
GFR with an average of 87.28 ± 70 mL/min/1.73m2. Proteinuria and
leukocyturia were observed in 31.71% and 19.51% respectively. Glycosuria and
hematuria with common frequencies of 2.44% of patients. Conclusion: The
prevention of renal toxicity of anticancer drugs always involves the precise
evaluation of renal function using the
Schwartz formula in children.