TITLE:
Effect of Tetracera potatoria Aqueous Extract on Mellitus Diabetes and Its Complication Preventions in Wistar Rats
AUTHORS:
Dhornycia Euroldyne Malaissou Tony, Raoul Ampa, Abraham Mayoke, Roger Pavel Boukongo, Hono Mavie Mambeke, Berthrand Stéphane Lingomo Wossolo, Martin Diatewa
KEYWORDS:
Mellitus Diabetes, Tetracera potatoria, Aqueous Extract, Alloxan
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.11 No.7,
July
26,
2023
ABSTRACT: Background: Diabetes is becoming a serious public health issue with expensive treatment that is less accessible to all patients in least developing countries. The traditional African pharmacopoeia offers accessible and lower cost alternative to diabetics’ treatments. Objective: The objective of this study was to evaluate the effect of the aqueous extract of Tetracera potatoria, on diabetes and the prevention of its complications in Wistar rats. In order to evaluate respectively the hypoglycaemic, anti-hyperglycaemic and antidiabetic activities. Methods: an aqueous extract at doses of 200 and 400 mg/kg was tested on normal rats and orally hyperglycaemic challenged rats by 10% glucose (3 g/kg), to induce diabetes by intraperitoneal injection of Alloxan at 50 mg/kg. The glycaemia monitoring, and the determination of biological parameters were accessed through ASAT, ALAT, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, glycated haemoglobin tests. Results: The aqueous extract at related doses administered to diabetic rats has significantly reduced the mean blood glucose levels in all diabetic rats at 55.56%, 63.34% and 62.38% compared to healthy control batches in the three batches treated. These doses improved the change in body weight compared to the healthy control group. There was an increase of 110.9%, 107.67% and 109.31% respectively after four weeks of treatment compared to the initial weight of the rats. The significant increase (p Conclusions: These results showed hypoglycaemic and antihy-perglycaemic, antidiabetic effects, preventing the installation of some diabetes related complications. The phytochemical parameters of the extract showed chemical compounds which would act the reduction of the putative diabetes and its complications. These indicators show the importance of medicinal plants on diabetes treatment.