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Varki, A., Kannagi, R., Toole, B., Cummings, R.D., Esco, J.D., Stanley, P., et al. (2017) Glycosylation Changes in Cancer. In: Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., et al., Eds., Essentials of Glycobiology, 3rd Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 2015-2017.

has been cited by the following article:

• TITLE: Tumor-Specific Histo-Blood Group Antigens: Apropos of Two Cases

  AUTHORS: Ferenc Baranyay

  KEYWORDS: Occult Breast Cancer, Krukenberg Metastasis, Incompatible Tumor-Specific, Histo-Blood Group Antigens

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.12 No.7, July 17, 2023

  ABSTRACT: Cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis the glycosyltransferases may suffer from posttranslation sequence modification. The author describes 2 autopsy cases, where in the background of the unusual metastatic tumor presentation, incompatible blood group antigenic determinants have been demonstrated using blood group specific lectins and monoclonal antibodies (mAb). In the first case, reported here, a 10-year-old girl developed an acute myeloid leukemia and died in a septic endotoxin shock after successful cytostatic treatment of a juvenile signet ring cell cancer of her colon. At autopsy there were no signs of tumor except bilateral apple-sized mucinous ovarian (Krukenberg) metastases. While she had erythrocyte phenotype of blood group A, the signet ring adenocarcinoma cells expressed blood group B incompatible antigenic determinants with lectin/mAb. In the second case, the autopsy of a 78-year-old female resulted in no macroscopic tumor sign except a moderately enlarged, ham hard spleen. Light microscopy revealed adenocarcinomatous infiltration in the splenic sinusoids. The patient had blood group O, while the metastatic cells in the spleen reacted with Breast Carcinoma Antigen (BioGenex) and incompatible anti-B Banderiaeasimplicifolia agglutinin I and anti-B mAb. It proved to be a case of an occult, completely regressed breast cancer. Based on these observations the expression of tumor specific incompatible blood group antigens might occur from time to time, mostly in adenocarcinomas. Accordingly, blood group-based specific immuno-oncotherapy could be considered in some cancer cases.