TITLE:
Profile of Female Hyperandrogenism at the Medical Clinic II: About 19 Cases
AUTHORS:
Michel Assane Ndour, Demba Diédhiou, Djiby Sow, Ibrahima Mané Diallo, Mouhamed Dieng, Fatou Gueye Astou Mbodj, Julie Borges Preira, Fatou Kiné Gadji, Muriel Diembou, Fama Ndiaye, El Hadj Mouhamadou Moustapha Thioye, Charles Halim, Anna Sarr, Maïmouna Ndour Mbaye
KEYWORDS:
Female Hyperandrogenism, Hirsutism, Senegal
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.13 No.5,
May
31,
2023
ABSTRACT: Introduction: Female hyperandrogenism is essentially manifested
by hirsutism. It is present in Senegal but not yet elucidated for lack of data.
This is why we proposed to study the profile of hyperandrogenism in our
context. Patients and Methods: This was an observational,
cross-sectional cohort study of 19 patients of reproductive age followed for
hyperandrogenism at the Medical Clinic II of Abass Ndao Hospital, from November
1st, 2019 to August 31st, 2021. Results: Our cohort consisted of
women with an average age of 25.3 years, single (73.7%), with a low
socioeconomic level (42.1%). A family history of hirsutism was found in 31.6%
of cases. The main reasons for consultation were a menstrual cycle disorder in
94.7% of cases, and hirsutism in 78.9% of cases. The latter was post-pubertal
(66.7%), with a slow or progressive evolution. The physical examination
revealed: hirsutism (100%) with an average modified Ferriman Gallwey score (mFG)
of 8.9 ± 5.8, acne (36.8%), hyperseborrhea (57.9%), major signs of virilization
(10.5%), acanthosis nigricans (47.4%) and galactorrhea (5.3%). Hormonal
explorations revealed an elevation of: testosterone (31.6%),
17-hydroxyprogesterone (5.3%), dihydrotestosterone (31.6%), and prolactin (10.5%). The ovarian morphology was
micropolycystic (84.2%). The etiological profile corresponded to polycystic ovarian
syndrome or PCOS (68.4%), ovarian hyperthecosis (10.5%), hyperprolactinemia
(10.5%), congenital adrenal hyperplasia or CAH (5.3%). Idiopathic hirsutism was
found in 5.3% of cases. Conclusion: Female hyperandrogenism is a less
frequent reason for consultation in endocrinology. It deserves to be further
evaluated in a large-scale study focused on epidemiological, clinico-biological
and etiological investigation, in order to assess its prevalence and better
define its profile in our context.