TITLE:
Tumor Local Microenvironment Is a Key Factor Affecting the Efficacy of PD-1 Inhibitor in Advanced Cervical Cancer: A Case Report and Literature Review
AUTHORS:
Mamady Keita, Xi Chen, Shiguan Wang, Yakun Liu, Jing Ma, Traoré Bangaly, Hong Liu
KEYWORDS:
Cervical Cancer, PD-1 Inhibitor, Recurrence and Metastasis, Radiotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.6,
June
29,
2023
ABSTRACT: Introduction: Conventional radiotherapy or chemotherapy is
ineffective in the treatment of recurrent
and metastatic cervical cancer. In recent years, immunotherapy has shown
promise in the treatment of various solid tumours,
including cervical cancer. The overall response rate of the PD-1/PD-L1 inhibitor in cervical cancer is 14% - 27%, and when combined with radiotherapy or conventional chemotherapy, the overall response
rate can be further improved. Case presentation: We report here a
case of a 49-year-old female patient presenting with two metastatic lesions of
cervical cancer after postoperative radiotherapy, the first was located in the
para-aortic region and the second in the presacral region. The enlarged
para-aortic lymph nodes had not previously
received radiotherapy, while the enlarged presacral lymph nodes had previously
received postoperative radiotherapy. Treatment results showed that the
recurrent presacral mass did not respond to the PD-1 inhibitor (camrelizumab) alone,
whereas the metastatic para-aortic lymph nodes responded favourably to
camrelizumab combined with low-intensity radiotherapy. Conclusion: PD1/PD-L1 inhibitors combined with radiotherapy
should make it possible to overcome the bottleneck of conventional
radiotherapy, improve patient prognosis or achieve better local control rates
with lower radiotherapy doses.