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Krushkal, J., Silvers, T., Reinhold, W.C., Sonkin, D., Vural, S., Connelly, J., Varma, S., Meltzer, P.S., Kunkel, M., Rapisarda, A., Evans, D., Pommier, Y. and Teicher, B.A. (2020) Epigenome-Wide DNA Methylation Analysis of Small Cell Lung Cancer Cell Lines Suggests Potential Chemotherapy Targets. Clinical Epigenetics, 12, Article No. 93. https://doi.org/10.1186/s13148-020-00876-8

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• TITLE: Differential Gene Expression Analysis on Workers Exposed to Pesticides: Genetic Damage and Cancer Susceptibility

  AUTHORS: Fábio Morato de Oliveira, Caio Fernando de Oliveira Pereira Passos, Hellen Miranda Campos, Gabriella Leite Sampaio, Leandro Hirata Mendes, Wagner Gouvêa dos Santos, Aline Monezi Montel, Tamara Rodrigues Lima Zanuzzi, Edlaine Faria de Moura Villela

  KEYWORDS: Pesticides, Genomic Instability, Gene Expression, Aurora Kinase, FISH, Micronucleus

  JOURNAL NAME: Open Access Library Journal, Vol.10 No.6, June 28, 2023

  ABSTRACT: We performed aurora kinase gene expression analysis, in combination with FISH and micronucleus test, in buccal mucosa cells isolated from agricultural workers to better understand the dynamics of genomic instability in these groups of professionals. Two out of a total of 97 agricultural workers who consented to participate in the study (39 men and 58 women) reported a history of cancer based on a previously applied questionnaire. The participants were 28.4 years on average and were categorized into three distinct groups based on their habits, as the “not exposed” group included 24 samples analyzed. The group classified as “indirectly exposed” consisted of 21 samples and those classified as “directly exposed” regarding their activities involved in pesticide preparation/application included 52 samples. Our results showed significant differences in the expression of AURKA and AURKB, among the groups (p