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Shinfuku, A., Shimazaki, T., Fujiwara, M., Sato, F., Watase, H., Numazaki, T., Kawakita, Y., Mutoh, M., Yamasaki, H., Takayama, N., Kato, S., Sugimoto, T. and Maruyama, J. (2018) Novel Compound Induces Erythropoietin Secretion through Liver Effects in Chronic Kidney Disease Patients and Healthy Volunteers. American Journal of Nephrology, 48, 157-164.
https://doi.org/10.1159/000492181

has been cited by the following article:

• TITLE: Cell-Based Biological Markers for Blood-Enriching Chinese Herbs: Erythropoietin Production in HepG2 Cells and Nitric Oxide Release in Human Umbilical Vein Endothelial Cells (HUVECs)

  AUTHORS: Hoi Yan Leung, Kam Ming Ko

  KEYWORDS: Blood-Enriching Chinese Herbs, Erythropoietin, Nitric Oxide

  JOURNAL NAME: Chinese Medicine, Vol.14 No.2, June 14, 2023

  ABSTRACT: Chinese tonifying herbs, which are classified into four functional categories (namely, Yang, Qi, Yin, Blood) are commonly used for restoring normal body function and the prevention of diseases. To explore cell-based biological markers for Blood-enriching Chinese herbs, we investigate the effect of 11 commonly used Blood-enriching herbs on erythropoietin (EPO) production in HepG2 cells. Herbs for nourishing Yin were tested for determining the specificity of Blood-enriching herbs in inducing EPO production. In addition, the effects of Blood-enriching herbs on nitric oxide (NO) production in both HepG2 cells and human umbilical vein endothelial cells (HUVECs) were also investigated. The results indicated that methanolic extracts of Blood-enriching herbs (but not Yin-nourishing herbs) showed characteristic pharmacological activity in inducing EPO production in HepG2 cells and NO release in HUVECs. The experimental findings, therefore, support the use of cell-based EPO production and NO release as biological markers for Blood-enriching Chinese tonifying herbs.