Article citationsMore>>
Thurmond, R.L., Venable, J., Savall, B., La, D., Snook, S., Dunford, P.J. and Edwards, J.P. (2017) Clinical Development of Histamine H4 Receptor Antagonists. In: Hattori, Y. and Seifert, R., Eds., Histamine and Histamine Receptors in Health and Disease. Handbook of Experimental Pharmacology, Vol. 241, Springer, Cham, 301-320. https://doi.org/10.1007/164_2016_130
has been cited by the following article:
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TITLE:
Vertigo and H4 Antagonist Effect on Vestibular Symptoms
AUTHORS:
Leena Saeed, Hanna Elbashir Mohamed Ali, Zeinab Abdalgadeer Ali Abdalla, Sarra Fadlalla Elabbas, Marwa Eltaj Eltayeb, Wafa Mukhtar Mohamed Mukhtar
KEYWORDS:
Vertigo, Dizziness, Peripheral Vertigo, Central Vertigo
JOURNAL NAME:
Open Access Library Journal,
Vol.10 No.5,
May
24,
2023
ABSTRACT: Vertigo is a condition when a patient feels that the objects around him are moving, and this condition can lead to falls and serious incidences. Vertigo has various etiologies including central, peripheral, psychogenic, and medication-induced vertigo. The most common cause is benign paroxysmal positional vertigo (BPPV) then Meniere’s disease and labyrinthitis should be in the differential diagnosis. Ruling out serious conditions such as stroke is important. Various treatment options are used for vestibular symptoms and vestibular rehabilitation shows a positive result. Management of vertigo is the same for a long time despite the partial effect, unwanted side effects due to some drugs, and the need for multiple medications to relieve the symptoms in some patients. More effective treatment with lesser side effects needs to be used. Recently some in vivo trials come into view that H4 antagonist such as SENS-111 is effective in treating vestibular symptoms. These medications work by blocking the action of histamine, a chemical messenger involved in the immune response. More clinical trials and research need to be done on this type of treatment and other treatment options as this will lead to positive transformation in the future.