TITLE:
Role of Polyethylene Glycol and Silica for Dissolution Enhancement of Cefuroxime Axetil: In-Vitro Performance Evaluation and Characterization
AUTHORS:
Mst. Boby Aktar Bithy, Milon Kumar Ghosh, Ashim Kumar, Md. Rafiqul Islam Khan, Mir Imam Ibne Wahed, Ranjan Kumar Barman
KEYWORDS:
Carplex-67, Cefuroxime Axetil, Improved Dissolution, PEG-4000, Solid Dispersion, Solvent Evaporation
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.14 No.5,
May
23,
2023
ABSTRACT: Cefuroxime Axetil (CA) a widely used cephalosporin antibiotic displays low aqueous solubility and high membrane penetrability. This results in its solubility driven variable and/or low oral bioavailability and therapeutic efficacy as a major drawback. Thus, most of the goal of our study was to increase the solubility as well as dissolution rate of CA using the simple and cost-effective solid dispersion (SD) method. At first, the SD formulations of CA were prepared at various weight ratios of Carplex-67 and PEG-4000 by solvent evaporation technique. These new formulations were then subjected to an in-vitro drug release performance study and tested for physicochemical characterization to distinguish the thermal behavior, crystallinity, interactions phenomena, and surface morphology. Among the formulated Cefuroxime Axetil Solid Dispersion (CSD), CSD-8 which contained CA, Carplex-67, and PEG-4000 at the weight ratio 1:3:2, respectively showed the most significant (p in-vitro dissolution in water, Gastric Simulated Fluid (GSF), and Intestinal Simulated Fluid (ISF). This study also showed a significant (p