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Ivanović, V., Demajo, M., Krtolica, K., Krajnović, M., Konstantinović, M., Baltić, V., Prtenjak, G., Stojiljković, B., Breberina, M., Nesković-Konstantinović, Z., Nikolić-Vukosavljević, D. and Dimitrijević, B. (2006) Elevated Plasma TGF-β1 Levels Correlate with Decreased Survival of Metastatic Breast Cancer Patients. Clinica Chimica Acta, 371, 191-193.
https://doi.org/10.1016/j.cca.2006.02.027

has been cited by the following article:

• TITLE: Plasma Levels of Transforming Growth Factor-Beta 1 in Women with Pelvic Organ Prolapse

  AUTHORS: Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Saori Nishijima, Seiji Matsumoto

  KEYWORDS: Cystocele, Pelvic Organ Prolapse, Transforming Growth Factor-Beta 1 (TGF-β1), Uterine Prolapse

  JOURNAL NAME: Open Journal of Urology, Vol.13 No.5, May 23, 2023

  ABSTRACT: Objective: In women with pelvic organ prolapse (POP), decreased expression of transforming growth factor-beta 1 (TGF-β1) has been shown in POP tissues. However, no studies have evaluated plasma TGF-β1 levels in patients with POP, so it is unknown whether they are also changed or not. Therefore, we compared plasma TGF-β1 levels in women with and without POP. Methods: Participants were 49 women with POP and 23 healthy control women. All participants were postmenopausal. We measured plasma TGF-β1 and compared data between patients with POP and controls, and between patients with uterine prolapse (UP, n = 19) and those with a cystocele (CC, n = 30). In addition, in patients, we assessed the POP quantification system (POP-Q) stage. Results: Plasma TGF-β1 levels were significantly lower in patients than in healthy controls. POP-Q stage was not significantly different between the UP and CC subgroups, but POP-Q stage IV was diagnosed in 63% of patients with UP and 7% of those with CC. Plasma TGF-β1 levels were significantly lower in the CC subgroup than in the UP subgroup. Conclusion: Plasma TGF-β1 is decreased in POP. It remains unclear whether the lower levels indicate a reduction in systemic TGF-β1 activity, but they can be assumed to reflect reduced TGF-β1 expression in POP tissues.