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Nikiforov, A., Dolle, C., Niere, M. and Ziegler, M. (2011) Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells. From Entry of Extracellular Precursors to Mitochondrial NAD Generation. Journal of Biological Chemistry, 286, 21767-21778.
https://doi.org/10.1074/jbc.M110.213298

has been cited by the following article:

• TITLE: Mechanism of Niacin Induced Hot Flushes and Suppression of Cholesterol

  AUTHORS: Thirugnana Subramanian

  KEYWORDS: Cholesterol Biosynthesis, NAD, Niacin, Niacinamide, Pyrophosphate

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.5, May 22, 2023

  ABSTRACT: Niacin or nicotinic acid is a form of B3 vitamin prescribed at higher concentrations for the suppression of cholesterol levels. Supplemental doses may cause very little or no side effects. However, higher concentrations of niacin cause hot flushes for most people. Here we propose a biochemical mechanism of niacin induced hot flushes. Orally taken prescription doses of niacin are converted to NAD with the liberation of excess pyrophosphate which in turn releases energy in the form of heat (hot flushes through capsaicin receptor) by the action of pyrophosphatases. The excess pyrophosphate may suppress cholesterol biosynthesis through feedback mechanism. The pathways of NAD and cholesterol biosynthesis were discussed with refence to the production and function of pyrophosphate.