TITLE:
Late Onset Combined Immune Deficiency (LOCID) Revealed by a Haemolytic Anaemia in a Child: A Case Report
AUTHORS:
Amal Hamami, Maria Rkain, Madiha Benhachem, Ayyad Ghannam, Aziza Elouali, Abdeladim Babakhoua, Noufissa Benajiba
KEYWORDS:
Haemolytic Anaemia, LOCID, Immune Deficiency, Child
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.13 No.3,
May
15,
2023
ABSTRACT: Variable
Common Immune Deficiency (VCID) is a very heterogeneous condition both
clinically and immunologically. It is a group of molecular abnormalities responsible for a defect in antibody
production leading to hypogammaglobulinemia often associated with
autoimmune and/or lymphoproliferative manifestations. Late Onset Combined Immune Deficiency (LOCID) is a
type of Variable Common Immune Deficiency (VCID) defined by a defect in
antibody production (IgG and IgA ± IgM
type), profound CD4 T-cell lymphopenia and frequent opportunistic infections. LOCID has been considered as
a distinct entity from VCID due to its particular clinical and immunological
profile.