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Forero, J.E., Avila, L., Taborda, N., Tabares, P., Lopez, A., Torres, F., Quinones, W., Bucio, M.A., Mora-Perez, Y., Rugeles, M.T., Joseph-Nathan, P. and Echeverri, F. (2008) In Vitro Anti-Influenza Screening of Several Euphorbiaceae Species: Structure of a Bioactive Cyanoglucoside from Codiaeum variegatum. Phytochemistry, 69, 2815-2819.
https://doi.org/10.1016/j.phytochem.2008.09.003

has been cited by the following article:

• TITLE: Codiaeum Variegatum Hydro Alcoholic Leaf Extracts and Their Fractions Inhibit Pro-Inflammatory Mediators in Vitro

  AUTHORS: Sylvain Pechangou Nsangou, Charifa Ngbetkom Mandou, Carine Matsigang Fondjou, Vigny Sayal Ngohoba, Edie Brice Enang II, Ibrahim Njingou, Emmanuel Mfotie Njoya, Frederic Nico Njayou, Paul Moundipa Fewou

  KEYWORDS: C. variegatum, Anti-Inflammatory, 5-Lipoxygenase, NO, TNF-α

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.5, May 11, 2023

  ABSTRACT: Codiaeum variegatum has been widely investigated for its biological proprieties ranging from the antiamoebic potential to the phytochemical analysis. The aim of the present study was to evaluate the anti-inflammatory potential of C. variegatum leaf extracts and fractions. A primary macrophage culture activated by Saccharomyces cereviseae (SC) was used to evaluate cell cytotoxicity and anti-inflammatory potential of the plant extracts and fractions. Macrophages were treated with different concentrations (0.1; 1; 10 and 100 μg/mL) of the extracts/fractions for the inhibition of 5-lipoxygenase activity, nitric oxide (NO) and Tumor Necrosis Factor Alpha (TNF-α) production. No significant difference was observed on cell viability in the presence of extracts and fractions at tested concentration during the incubation period. Extracts and fractions of C. variegatum inhibited the 5-lipoxygenase activity, NO and TNF-α production by viable primary mouse macrophages in a concentration-dependent manner. The fractionation process increased anti-inflammatory activity. Among fractions, HEF2, HEF3, HEF5, EEF1, EEF3 and EEF5 exhibited the best anti-inflammatory potential. C. variegatum extracts and fractions exhibited a greater anti-inflammatory potential throughout the inhibition of pro-inflammatory mediators such as NO, 5-Lox and TNF-α.