TITLE:
Clinical and Pathological Research Status of Multiple Pulmonary Nodules
AUTHORS:
Yun Wang, Shiqi Song, Jian Huang
KEYWORDS:
Lung Nodules, Originate, Pathology, Immune Microenvironment
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.4,
April
26,
2023
ABSTRACT: With the
changes in disease spectrum and the popularization of screening of low-dose
spiral CT (CT) in the chest, more and more pulmonary nodules have been
detected, most of which are bipulmonary multiple nodules. The existence of
multiple pulmonary nodules means that it may be a pathological state of benign
and malignant co-existence. The origin and evolution of pulmonary nodules in
different histopathological states have a great impact on the choice of
treatment methods. In recent years, the rise of immunotherapy has brought a
breakthrough in the treatment of refractory lung cancer. However, some patients
are still ineffective in immunotherapy, which may be related to the immune
microenvironment where nodules are proportioned in different components in
different pathological states. This review article mainly predicts the
development process of nodules by analyzing the origin of multiple pulmonary
nodules and the immune microenvironment of nodules in different pathological
conditions, so as to provide guidance for clinical treatment.