TITLE:
Pre-Sacral Chordomas, about Two Cases and Review of the Literature
AUTHORS:
Oumaima Siyouri, Khaoula Alaoui Ismaili, Imane Stitou, Mohammed Ismaili, Hajar Medyouni, Jihane Chouef, Lamiae Amaadour, Karima Oualla, Zineb Benbrahim, Samia Arifi, Nawfel Mellas
KEYWORDS:
Chordomas, Imatinib, Radiotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.4,
April
26,
2023
ABSTRACT: The World Health Organization (WHO) defines chordoma as a malignant tumor
of intermediate or low grade, developing at the expense of embryonic remnants
of the notochord. These tumors represent 8.4% of all malignant bone tumors. We
report 2 cases collected in the medical oncology department at the CHU Hassan
II in Fes. In whom the clinical examination revealed a mass and/or signs of
loco-regional compression. The tumor was located in the sacrum in both
patients. The diagnosis was based on the data of the anatomopathological
examination showing the association of a lobulated architecture with classic physaliphore
cells and a mucoid intercellular substance. Immunohistochemistry was performed
for both patients. The principle of therapeutic management was based on
radiotherapy and targeted therapy since surgery was difficult given the local
tumor extension.