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Magnusdottir, K.S., Tryggvadottir, E.A., Magnusdottir, O.K., Hrolfsdottir, L., Halldorsson, T.I., Birgisdottir, B.E., Hreidarsdottir, I.T., Hardardottir, H. and Gunnarsdottir, I. (2021) Vitamin D Status and Association with Gestational Diabetes Mellitus in a Pregnant Cohort in Iceland. Food & Nutrition Research, 65, Article No. 5574.
https://doi.org/10.29219/fnr.v65.5574

has been cited by the following article:

• TITLE: Maternal Vitamin D Deficiency and Risk of Development of Gestational Diabetes Mellitus: A Scoping Review

  AUTHORS: Yureka Demini Wimalajeewa, Usha Pushkala Kumari Hettiaratchi, Thamara Dilhani Amarasekara, Shamini Prathapan, Mathota Arachchilage Madura Mangala Jayawardane

  KEYWORDS: Gestational Diabetes Mellitus, Maternal, Vitamin D Deficiency

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.4, April 23, 2023

  ABSTRACT: Background: Maternal vitamin D status is a critical determinant during pregnancy, because it plays an important role in the body not only in calcium homeostasis and bone remodeling, but also in the glucose metabolism. Vitamin D deficiency is associated with adverse pregnancy outcomes including gestational diabetes mellitus. Objective: To review evidence on the association between maternal vitamin D deficiency and incidence of gestational diabetes mellitus (GDM). Methods: PRISMA for scoping review guideline and scoping review guidelines of Arksey & O’Malley (2005) was followed in methodological process. A comprehensive search strategy was carried out across the Google Scholar and PubMed from January 2012 to December 2022, using the search terms of “gestational diabetes mellitus/pregnancy outcomes” combined with “vitamin D”, “cholecalciferol” or “25-hydroxyvitamin D” and/or “deficiency”. Articles were screened at the title and the abstract level and at full text by three co-investigators of the study independently with a fourth reviewer resolving discrepancies. Research studies published only in English language were selected. Research using pregnant mothers with multiple pregnancy and chronic diseases was excluded. Results: After screening 134 titles and abstracts, finally 55 original research articles were selected. It involved 48 observational studies and 7 Randomized Control Trials (RCT). Only 30 research articles had found an association between maternal vitamin D deficiency and GDM. Conclusion: As results of previous studies are mixed and inconclusive, further research including more RCTs is needed to clarify the exact mechanism of vitamin D on glucose metabolism during pregnancy.