TITLE:
Effects of Sarcocephalus latifolius Fruits Extract on Paracetamol-Induced Liver Damage in Wistar Rats
AUTHORS:
Filkpièrè Léonard Da, Basile Tindano, Géneviève Zabre, Karim Sakira, Balé Bayala, Raymond G. Belemtougri, Philippe Horlait
KEYWORDS:
Rats, Paracetamol, Hepatotoxicity, Sarcocephalus latifolius, Silymarin
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.14 No.4,
April
21,
2023
ABSTRACT: Background
and Aim: Sarcocephalus
latifolius is a medicinal plant commonly used in traditional
medicine to treat various diseases. The aim of the present study is to
evaluate the hepatoprotective activity of Sarcocephalus
latifolius fruits aqueous extract against paracetamol-induced liver damage
in rats. Material and Methods: Aqueous extract of Sarcocephalus latifolius fruits at doses of 100, 250 and 500 mg/kg
were administered orally to rats with paracetamol-induced hepatotoxicity (1 g/kg).
The treatment with the extract and paracetamol lasted 7 days. Silymarin (50 mg/kg) was given as
reference control. All tested drugs were administered orally. Results: Our results show that the Sarcocephalus
latifolius fruits extract induced a significant reduction (p Conclusion: Aqueous extract of Sarcocephalus
latifolius fruits has hepatoprotective activity against paracetamol-induced
hepatotoxicity in rats. But it would be important to evaluate the activity of
aqueous extract of Sarcocephalus
latifolius fruits on oxidative stress parameters in vivo in rats.