TITLE:
Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents
AUTHORS:
Tianzhi Zhang, Chao Liang, Guangchang Shan, Danting Su
KEYWORDS:
Children and Adolescents, Thyroid Papillary Carcinoma, Clinicopathological Features, BRAF Mutation
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.14 No.4,
April
19,
2023
ABSTRACT: Objective: To
investigate the clinicopathologic features of differentiated thyroid carcinoma
in children and adolescents. Methods: The
clinical data of 7 children and adolescents with differentiated thyroid
carcinoma were retrospectively analyzed, and the clinicopathologic features of
differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF
mutation. Results: There were 7 cases of thyroid papillary carcinoma. The
mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ±
1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and
adolescents, the lesion volume was larger, membrane invasion and vascular
cancer thrombus were more likely to occur, BRAF mutation was less common, and
the difference was statistically significant. Conclusion: Children
and adolescents with differentiated thyroid carcinoma are more aggressive and
prone to membrane invasion and lymph node metastasis; BRAF mutation is less
common than in adults.