TITLE:
Impact of Ursodeoxycholic Acid on Gall Stone Formation Post Bariatric Surgery
AUTHORS:
Afra Amin, Yasir Arafat, Mohammed Alkhayat, Mohannad Eledreesi, Sultan Alotaibi, Omniyyah Bakheet
KEYWORDS:
Ursodeoxycholic Acid, Gallstone, Bariatric Surgery
JOURNAL NAME:
Surgical Science,
Vol.14 No.3,
March
31,
2023
ABSTRACT: Introduction: Bariatric surgery is identified as highly effective therapy for obesity and help to loss wight that is become important public health
priority because it increases the risk of condition including diabetes,
cardiovascular disease, and several types of cancer whether by accomplishing mini-gastric bypass, Gastric bypass (Roux-en-Y) and sleeve
gastrectomy [1] rapid weight loss increased incidence risk of gall
stone formation [2]. Ursodeoxycholic acid is a bile acid which affect a reduction in
cholesterol in biliary fluid primary by dispersing the cholesterol and forming
a liquid-crystal phase [2], it’s can play a significant role in preventing of gall stone formation. Objective: Study potential effect of Ursodeoxycholic acid
(UDCA) on gall stone formation after bariatric surgery. Methods: This
study Cross-sectional Trials, review of all patient underwent bariatric surgery November 2021-Jun
2022, Taif Military Hospital in the department of
surgery, the sample of study will be around 143 participants or more, data
collection all patient underwent bariatric surgery. Results: A Total of 160 patients underwent bariatric surgery in Taif Armed Forces Hospitals from 2015 to 2021. Of these, 53
were male (33.1%) and 107 were female (66.9%). only 33 patients (20.6%)
received Ursodeoxycholic acid, and 127 patients (79.4%) weren’t proscribed for
them. However, 40 patients (25%) develop gall stone and underwent
cholecystectomy, three of them were on Ursodeoxycholic acid (9%) and 37
patients weren’t on Ursodeoxycholic acid (29%). which shows that Ursodeoxycholic acid remarkable reduce the
risk of gall stone formation post wight reduction surgery. Conclusion: In
conclusion, bariatric procedures come with the risk of leading to the formation
of gallstones. This is especially in the stage when a patient experiences rapid
loss of weight. This is why a preventive measure is necessary and UDCA have
been considered for this purpose.
This study has shown that patients who use UDCA are less bound to have gallstone formations.