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Boerlage, T.C.C., Haal, S., de Brauw, L.M., Acherman, Y.I.Z., Bruin, S., van de Laar, A.W.J.M., Moes, D.E., van Wagensveld, B.A., de Vries, C.E.E., van Veen, R., Schouten, R., Dijkgraaf, M.G., Fockens, P., Gerdes, V.E.A. and Voermans, R.P. (2017) Ursodeoxycholic Acid for the Prevention of Symptomatic Gallstone Disease after Bariatric Surgery: Statistical Analysis Plan for a Randomised Controlled Trial (UPGRADE Trial). BMC Gastroenterology, 17, Article No. 164.
https://doi.org/10.1186/s12876-017-0674-x

has been cited by the following article:

• TITLE: Impact of Ursodeoxycholic Acid on Gall Stone Formation Post Bariatric Surgery

  AUTHORS: Afra Amin, Yasir Arafat, Mohammed Alkhayat, Mohannad Eledreesi, Sultan Alotaibi, Omniyyah Bakheet

  KEYWORDS: Ursodeoxycholic Acid, Gallstone, Bariatric Surgery

  JOURNAL NAME: Surgical Science, Vol.14 No.3, March 31, 2023

  ABSTRACT: Introduction: Bariatric surgery is identified as highly effective therapy for obesity and help to loss wight that is become important public health priority because it increases the risk of condition including diabetes, cardiovascular disease, and several types of cancer whether by accomplishing mini-gastric bypass, Gastric bypass (Roux-en-Y) and sleeve gastrectomy [1] rapid weight loss increased incidence risk of gall stone formation [2]. Ursodeoxycholic acid is a bile acid which affect a reduction in cholesterol in biliary fluid primary by dispersing the cholesterol and forming a liquid-crystal phase [2], it’s can play a significant role in preventing of gall stone formation. Objective: Study potential effect of Ursodeoxycholic acid (UDCA) on gall stone formation after bariatric surgery. Methods: This study Cross-sectional Trials, review of all patient underwent bariatric surgery November 2021-Jun 2022, Taif Military Hospital in the department of surgery, the sample of study will be around 143 participants or more, data collection all patient underwent bariatric surgery. Results: A Total of 160 patients underwent bariatric surgery in Taif Armed Forces Hospitals from 2015 to 2021. Of these, 53 were male (33.1%) and 107 were female (66.9%). only 33 patients (20.6%) received Ursodeoxycholic acid, and 127 patients (79.4%) weren’t proscribed for them. However, 40 patients (25%) develop gall stone and underwent cholecystectomy, three of them were on Ursodeoxycholic acid (9%) and 37 patients weren’t on Ursodeoxycholic acid (29%). which shows that Ursodeoxycholic acid remarkable reduce the risk of gall stone formation post wight reduction surgery. Conclusion: In conclusion, bariatric procedures come with the risk of leading to the formation of gallstones. This is especially in the stage when a patient experiences rapid loss of weight. This is why a preventive measure is necessary and UDCA have been considered for this purpose. This study has shown that patients who use UDCA are less bound to have gallstone formations.