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Naheed, A., Ram, P.K., Brooks, W.A., Hossain, M.A., Parsons, M.B., Talukder, K.A., Mintz, E., Luby, S. and Breiman, R.F. (2010) Burden of Typhoid and Paratyphoid Fever in a Densely Populated Urban Community, Dhaka, Bangladesh. International Journal of Infectious Diseases, 14, E93-E99.
https://doi.org/10.1016/j.ijid.2009.11.023

has been cited by the following article:

• TITLE: Occurrence of Salmonella Enteric Serovar Typhi Antibodies among Blood Donors in Ghana

  AUTHORS: Akua Obeng Forson, Seth Adu-Adjei, Michael Olu-Taiwo, Benjamin Tetteh Mensah, Alexander Martin-Odoom

  KEYWORDS: S. Typhi, Blood Donors, Seroprevalence, Ghana

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.3, March 30, 2023

  ABSTRACT: Background: Donated blood contaminated with S. Typhi can cause post-transfusion sepsis. This study aimed to determine the correlation between some risk factors of typhoid fever and seroprevalence of antibodies against S. Typhi among blood donors. Methodology: Following informed consent, socio-demographic and information on risk factors of typhoid infection was obtained using pre-structured questionnaires from 400 apparently healthy blood donors at the Tema General Hospital. Blood was also collected for serology and cultured for identification of pathogens by standard bacteriological method. Results: Blood culture did not reveal any S. Typhi isolate out of the tested 400 (348 males and 52 females) samples from apparently healthy blood donors. However, IgM and IgG antibody seroprevalence of 9.3% and 3.5% were detected. Age group of 17 - 24 years was the highest risk group, persons with a history of typhoid infection, and sources of drinking water were major risk factors for typhoid infection. It was also observed that prevalence of IgM was highest among new donors (62.2%), but lower in donors with a history of 1 to 3 blood donations (32.4%) and least among regular donors (>3 donations (5.4%)). In addition, typhoid prevention awareness and typhoid knowledge (knowledge about typhoid transmission) among the donors were poor (4.3% and 5.9% respectively). Conclusions: This study has shown an overall seroprevalence of 9% and 3.5% for IgM and IgG antibodies respectively among blood donors in the Tema area in Ghana. We advocate for the mandatory screening of donor units intended for transfusion for S. Typhi. Furthermore, there is an urgent need for the health education of all persons in Ghana on preventive measures and the spread of S. Typhi.