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Zhang, C., Xie, Y., Chen, H., Lv, L., Yao, J., Zhang, M., Xia, K., Feng, X., Li, Y., Liang, X., Sun, X., Deng, C. and Liu, G. (2020) FOXO4-DRI Alleviates Age-Related Testosterone Secretion Insufficiency by Targeting Senescent Leydig Cells in Aged Mice. Aging, 12, 1272-1284.
https://doi.org/10.18632/aging.102682

has been cited by the following article:

• TITLE: Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery

  AUTHORS: Min Seob Lee, Hyuk Jung Kwon, Yonjung Kim, Na Young Min, So Young Lee, Isaac Kise Lee

  KEYWORDS: Aging, Biomarkers, Epigenetics, Methylation, Geriatric Disease

  JOURNAL NAME: Advances in Aging Research, Vol.12 No.2, March 28, 2023

  ABSTRACT: Background: Aging is a complex biological process that is associated with a decline in physiological functions and an increased risk of age-related diseases. Despite advances in molecular biology and genetics, the underlying mechanisms of aging remain largely unknown. Study: The identification of biomarkers of aging would provide a powerful tool for monitoring the effects of aging and for developing interventions to improve healthspan. Aging is associated with alterations in genetics, epigenetic marks, telomere shortening, cell senescence, and changes in the expression of genes involved in metabolism, inflammation, and DNA damage repair. Epigenetic changes, including modifications to DNA methylation and histone acetylation patterns, play a critical role in the aging process. As we age, these changes can lead to altered gene expression and contribute to the development of age-related diseases such as cancer, Alzheimer’s disease (AD) and cardiovascular disease (CVD). Conclusion: The discovery of aging biomarkers that are sensitive to these epigenetic changes has the potential to revolutionize our understanding of the aging process and inform the development of interventions to improve healthspan and extend lifespan.