TITLE:
Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery
AUTHORS:
Min Seob Lee, Hyuk Jung Kwon, Yonjung Kim, Na Young Min, So Young Lee, Isaac Kise Lee
KEYWORDS:
Aging, Biomarkers, Epigenetics, Methylation, Geriatric Disease
JOURNAL NAME:
Advances in Aging Research,
Vol.12 No.2,
March
28,
2023
ABSTRACT: Background: Aging
is a complex biological process that is associated with a decline in
physiological functions and an increased risk of age-related diseases. Despite
advances in molecular biology and genetics, the underlying mechanisms of aging
remain largely unknown. Study: The identification of biomarkers of aging
would provide a powerful tool for monitoring the effects of aging and for
developing interventions to improve healthspan. Aging is associated with
alterations in genetics, epigenetic marks, telomere shortening,
cell senescence, and changes in the expression of genes involved in metabolism,
inflammation, and DNA damage repair. Epigenetic changes, including
modifications to DNA methylation and histone acetylation patterns, play a
critical role in the aging process. As we age, these changes can lead to
altered gene expression and contribute to the development of age-related
diseases such as cancer, Alzheimer’s disease (AD) and cardiovascular disease
(CVD). Conclusion: The discovery of aging biomarkers that are sensitive
to these epigenetic changes has the potential to revolutionize our
understanding of the aging process and inform the development of interventions
to improve healthspan and extend lifespan.