TITLE:
Antibiotic Resistance in the Uropathogenic Enterobacteria Isolated from Patients Attending General Reference Hospital (GRH) of Niamey, Niger
AUTHORS:
Alassane Halawen Mohamed, René Dembélé, Chaibou Salaou, Alix Bénédicte Kagambèga, Hiliassa Coulibaly, Frédéric François Bado, Alio Mahamadou Fody, Laouali Boubou, Alkassoum Ibrahim, Eric Adehossi Omar, Mauricio Arcos Holzinger, Nicolas Barro
KEYWORDS:
Antibiotic Resistance, Urinary Tract Infections, Enterobacteriaceae, Viteck-2, Niger
JOURNAL NAME:
Open Journal of Medical Microbiology,
Vol.13 No.1,
March
23,
2023
ABSTRACT: Background: Urinary tract
infections (UTIs) are a frequent reason for consultation and lead to a
significant and sometimes inappropriate prescription of antibiotics. The latter
favors antibiotic resistance and an increase in mortality as well as the cost
of treatment. The present study aims to contribute to the fight against
antibiotic resistance of enterobacteria. Methods: This is a prospective
study from January to December, 2021 in the Microbiology laboratory of the
General Reference Hospital (GRH) of Niamey including 3369 urine samples. The
antibiotic resistance of enterobacteria was determined using the Viteck-2 method. Results: At least 280 strains of Enterobacteriaceae were isolated from the patient’s urine. Among these strains, Escherichia coli was the most predominant (74.64%), followed by Klebsiella pneumoniae (16.07%) and Enterobacter cloacae (7.14%) and other
enterobacteria 2.15%. These Enterobacteriaceae are more common in community patients than in hospitalized patients. The
average age of patients is 52 years and the age group most affected by
these enterobacteria is 46 - 60 years (23.33%). The female sex is the most affected sex with (51.07%)
against (48.97%) for the male sex with 1.04 as sex ratio. The hospitalization
departments most affected by these enterobacteria are Nephrology (29.23%) and
Endocrinology (21.54%). Up to 75% of the Enterobacteriaceae isolates show high resistance to ampicillin, amoxicillin-clavulanic acid,
ticarcillin, piperacillin-tazobactam, cefoxitin, cefixime, ceftazidime,
ceftriaxone, cotrimoxazole, nalidixic acid and ofloxacin. Conclusion:
The high rate of antibiotic resistance among enterobacteria in urine is of
concern. Only a few Enterobacteriaceae show low resistance to ertapenem, imipenem, amikacin, gentamicin, fosfomycin
and nitrofurantoin. Therefore, these antibiotics are recommended as first line
treatment for urinary tract infections.