TITLE:
Sino-Nasal Malignant Melanoma: A Case Report
AUTHORS:
Grace Wong Yan Yee, Ranveer Singh Gill, Guhan Kumarasamy, Chelvam Rajesvaran, Sharmila Rajendran
KEYWORDS:
Malignant Melanoma, Sino-Nasal, Immunohistochemistry
JOURNAL NAME:
International Journal of Otolaryngology and Head & Neck Surgery,
Vol.12 No.2,
March
16,
2023
ABSTRACT: Melanoma is a malignant tumor and is commonly found second least in the head and neck region, with approximately 10% - 25% of melanomas followed by ear (8% - 11%). We reported a case of sino-nasal malignant melanoma in a 46-year-old Asian lady who presented with epistaxis and dysphagia. By nasoendoscopy and CT scan imaging, the diagnosis of sino-nasal malignant melanoma was later confirmed by histopathology examination along with immunohistochemistry by using Melan A and S100. Malignant melanoma in the head and neck is rare and has a poor prognosis. There has been an increase in the incidence of 5% per year and mortality at 2% per year. This dictates malignant melanoma has rapidly increased compared to any other cancer except lung cancer in women and has contributed to the third highest number of deaths among all cancers. The mortality rate has also increased, and that is attributed to the negligence of symptoms during the initial period. This usually leads to patients seeking consultation during the advanced stage of the disease. In conclusion, this paper is to report that malignant melanoma may be one of the differentials of sino-nasal masses, and it may mimic nasopharyngeal carcinoma in its presentation.