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Lin, Y.C., Chen, J.S., Wang, C.H., Wang, H.M., Liaul, C.T., Yang, T.S., et al. (2001) Weekly High-Dose 5-Fluorouracil (5-FU), Leucovorin (LV) and Bimonthly Cisplatin in Patients with Advanced Gastric Cancer. Japanese Journal of Clinical Oncology, 31, 605-609.
https://doi.org/10.1093/jjco/hye130

has been cited by the following article:

• TITLE: 5-Fluorouracil-Induced Hyperammonemia Encephalopathy in a Patient with Gastric Cancer

  AUTHORS: Toky Rakotoarivo, Vonjy Andrianarison, Ny Ony Andrianandrasana, Malala Razakanaivo, Florine Rafaramino

  KEYWORDS: Encephalopathy, Gastric Cancer, Hyperammonemia, 5-Fluororuracil

  JOURNAL NAME: Journal of Cancer Therapy, Vol.14 No.2, February 28, 2023

  ABSTRACT: Chemotherapy with 5-fluorouracil (5 FU) has been widely used to treat advanced gastric cancer. Knowing the side effects is therefore important in order to better prevent them. Fluoropyrimidine-induced hyperammonemic encephalopathy is a rare complication and characterized neurological status with elevated ammonia level without radiological abnormalities. We report the first case of 5 FU-induced hyperammonemic encephalopathy in women patients on induction chemotherapy for gastric cancer in Madagascar. His ammonia level (NH3) was 102 μmol/l. The patient recovered from his confusional state after two days of treatment with hyperhydration and vitamin therapy.