TITLE:
Prothrombotic Effect of Serum Uric Acid in Hypertensive Patients
AUTHORS:
Maria Papavasileiou, Dionysios Aravantinos, Georgios Moustakas, Alexandra Karamanou, Stylianos Patsianis, Andreas Pittaras
KEYWORDS:
Hypertension, Uric Acid, Blood Clotting Factors, Pro-Thrombotic Factors
JOURNAL NAME:
Open Access Library Journal,
Vol.10 No.2,
February
24,
2023
ABSTRACT: Aim: The purpose of this study was to investigate the possible relationship of serum uric acid levels (SUA), in hypertensive patients treated or not, with blood clotting factors. Design and Methods: The study population consisted of 1297 hypertensive patients (46% men) treated (53%) or newly diagnosed untreated (mean age 57.8 years, mean office systolic/diastolic blood pressure -Ms/DBPo-: 147.9/91.6 mmHg, mean office heart rate -mHRo-: 75 ± 11.1 beats per minute, mean body mass index-Mbmi-: 28.2 ± 4.9 kg/m2, mean waist/hip ratio -Mw/H-: 0.88 ± 0.84 In the aforementioned patients SUA and blood clotting factors were measured, such as fibrinogen, international normalized ratio (INR) and serum homocysteine (Hcys). Moreover in a subgroup (N = 323) of the above mentioned study population, 323 patients, blood antithrombin III (ATIII), and D-dimers were also measured. Finally, in a small subgroup (N = 42) of the above mentioned study population of 42 patients, blood plasminogen activator inhibitor-1 (PAI-1) was measured. Values obtained were interrelated with Pearson correlation. Results: The following significant correlations were observed: SUA vs fibrinogen (r = 0.164; p Conclusions: In hypertensive patients, SUA levels correlate significantly with blood clotting factors, possibly suggesting a prothrombotic effect of SUA in those patients.