TITLE:
Provision of Fertility Preservation for Young Women with Early-Stage Breast Cancer
AUTHORS:
Rosliza Shafie, Danielle Elizabeth Robson, Dinithi Samarawickrama, William Ledger
KEYWORDS:
Fertility Preservation, Ovarian Reserve, Young Women, Early-Stage Breast Cancer
JOURNAL NAME:
Advances in Reproductive Sciences,
Vol.11 No.1,
February
21,
2023
ABSTRACT: Breast cancer is the most common cancer in women worldwide, constituting25% of all cancer diagnoses. Even though it is only affecting 4%-6% of women underthe age of 40, it remainsthe most common malignancy among youngerpatients. Advancement in the treatment and earlier detection givesexcellent 5yearsofsurvival. However,thestandard treatmentthatcomprises surgical-chemoradiation therapy or hormonal treatment often resultsinanincreasedincidenceof treatment-induced infertility. Therefore,adding fertility preservation toprimary cancer treatment may offer the best opportunity for future fertility.However,despite advancementsin Assisted Reproductive Technology (ART),the uptake of fertility servicesin this group remainslow. In this review,we highlighted the effect of all breast cancer treatmentsonwomen’s fertility, the effectiveness and safety of ART in breast cancer patientsas well asthesafety of pregnancy in breast cancer survivors. Our aimisto improve awareness of fertility preservation for breast cancer to ensure all women diagnosed with breastcancer have multidisciplinary approacheswith early referral to fertility specialiststodiscuss regarding potential risksand benefitsof fertility preservation to improvetheuptake of fertility preservation among this group of patients.