TITLE:
Vaginal Progesterone (VP) versus VP plus Intermittent Intramuscular Progesterone (IMP) Use in Frozen/Thawed Blastocyst Transfer Cycles: An Observational Cohort Study
AUTHORS:
Serdar Celik, Dilek Cengiz Celik
KEYWORDS:
Vaginal Progesterone Supplementation, Progesterone Supplementation, IVF, Cryopreserved Embryo Transfer, Hormone Replacement Therapy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.13 No.2,
February
16,
2023
ABSTRACT: Objective: Comparison of vaginal progesterone (VP) versus VP and intermittent
intramuscular progesterone (IMP) use in frozen/thawed blastocyst transfer
cycles. Study Design: A single center retrospective analyses of 470
elective FET cycles which were performed between January 2015 and September
2019 were evaluated. Patients were divided into two groups. Control group was
consisted of VP (n = 272), the study group was consisted of VP plus IMP (n = 198)
users. Results: The number of transfer attempts in control and study groups
was 272 and 198, respectively.
Age (29.8 ± 4 vs 30.6 ± 4; p = 0.09), BMI (22 ± 2 vs 21.9 ± 3; p = 0.79) and
the number of transferred embryos (1.4 ± 0.5 vs 1.4 ± 0.5; p = 0.48) were comparable
between groups. Altough, implantation rates (43.7% vs 43.6%; p = 0.9), ectopic pregnancy (0.8%
vs 0.3%; p = 0.46) and abortion rates (8.2% vs 4.8%; p = 0.07) were similar. Biochemical
pregnancy rate (8.4% vs 3.4%
p = 0.01) in control group and ongoing pregnancy rate (OPR) (27.9% vs 38.1%; p
= 0.005) in study group were significantly higher. Conclusion: Within
the FET cycles in which good quality blastocyst are being transferred
additional IMP supplementation to VP may increase OPR while reducing the
biochemical pregnancy rate.