TITLE:
Factors Predicting Transformation of Non-Severe Pre-Eclampsia into Pre-Eclampsia with Severe Features
AUTHORS:
Mohammed Mahmoud Samy, Ahmed Nagy Abdul-Rahman Younis, Karim Mohammed Labib
KEYWORDS:
Pre-Eclampsia, Blood Pressure, Body Mass Index, Platelet Count
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.13 No.2,
February
13,
2023
ABSTRACT: Background: Pre-eclampsia (PE), a complex, multisystem, pregnancy-associated hypertensive disorder, typically developing after the 20th week of gestation, that
complicates 2% - 8% of pregnancies, is a leading cause of neonatal and maternal mortality and morbidity. Aim of the Work: To identify different factors predicting
transformation of non-severe pre-eclampsia in to pre-eclampsia with severe features.Patients
and Methods: This
prospective cohort study was conducted at tertiary care hospital at Ain Shams
University hospitals from June 2021 till January 2022 and performed on total of
100 patients who diagnosed as non-severe pre-eclampsia after exclusion of
severity features. Results: The current study revealed that transformation to severe pre-eclampsia occurred in 33% of the studied cases. Body mass index
(BMI), past and family histories of preeclampsia statistically were
significantly higher in cases transformed into preeclampsia with severe
features. Admission blood pressure, albumin dipstick, Oligohydramnios and IUGR
statistically were significantly higher in cases with transformation from
non-severe pre-eclampsia into pre-eclampsia with severe features. Platelet count statistically was significantly lower
in cases with transformation from non-severe pre-eclampsia into pre-eclampsia
with severe features Conclusion: Our study results identified the most important clinical risk
factors for transformation to severe features of pre-eclampsia from non-severe
features and provided new information on the level of risk associated with
specific combinations of risk factors (BMI ≥ 35.4, admission systolic blood pressure, admission diastolic blood pressure,
albumin dipstick 4+ and platelets count) with low significant diagnostic
performance in predicting transformation from non-severe
pre-eclampsia into pre-eclampsia with severe features.