TITLE:
Assessing the Effect and Use of an Aqueous Form of a Common Ghanaian Leaves Extract, Chromolaena odorata (Acheampong Leaf) on Coagulation Test Parameters in Vitro
AUTHORS:
David Ntiamoah Ofosu, Akwasi Asamoah, Ransford Mawuli Tuekpe, Edmond Opoku Addo, Elijah Kofi Takyi, Alex Addai
KEYWORDS:
C. odorata, Acheampong Leaf, Prothrombin Time, Activated Partial Thromboplastin Time
JOURNAL NAME:
Open Access Library Journal,
Vol.10 No.1,
January
19,
2023
ABSTRACT: Background: In Ghana, the use of Chromolaena odorata (Acheampong Leaf) as a first aid material to control bleeding is a very common practice in the rural areas. This study sought to assess the coagulation effect of aqueous extract of C. odorata (Acheampong Leaf) leaves on the coagulation profile. Methods: In this experimental study, freshly obtained C. odorata leaves extract was made using distilled water. Blood samples were taken from 197 non-hemophiliacs. PT and aPTT tests were tested with the extract. Results: The study result showed significantly reduced PT results of the study participants (17.89 ± 3.06 s to 16.43 ± 2.51 s, p Conclusion: C. odorata proved to be strongly effective in promoting coagulation (procoagulant) in vitro. We recommend studies to isolate and purify the active chemical compound in C. odorata leaves to further the pathway and mechanism of action.