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Vouros, A., Gehring, T.V., Szydlowska, K., Janusz, A., Tu, Z., Croucher, M., Lukasiuk, K., Konopka, W., Sandi, C. and Vasilaki, E. (2018) A Generalised Framework for Detailed Classification of Swimming Paths Inside the Morris Water Maze. Scientific Reports, 8, Article No. 15089.
https://www.nature.com/articles/s41598-018-33456-1

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• TITLE: BI-D1870 Causes the Rats’ Learning and Memory Acquisition Ability Impairment

  AUTHORS: Chaojie Zhang, Ke He, Caixia Li, Yazhen Shang

  KEYWORDS: BI-D1870, Learning and Memory Acquisition Impairment, Morris Water Maze, RSK Inhibitor

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.1, January 19, 2023

  ABSTRACT: Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in the control group were intraperitoneally injected with saline, while those in the solvent control group were intraperitoneally injected with DMSO + sulfobutyl-β-cyclodextrin solvent, and those in the BI-D1870 group were intraperitoneally injected with BI-D1870. All the rats’ appearance and behavior were daily observed, and body weight was recorded on the day 15, 30, 45, 60, 75 and 82 of BI-D1870 injected. Morris water maze was used to screen the rats’ learning and memory acquisition ability on the day 22 - 25, 52 - 55, and 82 - 85 of training by BI-D1870 treated. The successful rates of the rats’ memory impairment were respectively calculated for three times screening. Results: During the whole experiment, there was no obvious difference in appearance and fur color in all rats. The rats’ agitation began to appear on the day 10th of BI-D1870 given. The agitation rats’ number and rats’ body weight gradually increased along with BI-D1870 treated (P P Conclusion: Intraperitoneal injection of BI-D1870 can induce the rats’ learning and memory acquisition ability disorder.