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Gichohi-Wainaina, W.N., Melse-Boonstra, A., Swinkels, D.W., Zimmermann, M.B., Feskens, E.J. and Towers, G.W. (2015) Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population. The Journal of Nutrition, 145, 945-953.
https://doi.org/10.3945/jn.114.209148

has been cited by the following article:

• TITLE: Maternal TMPRSS6 Gene Polymorphism rs855791SNP in Women with Preeclampsia

  AUTHORS: Yasir I. B. Ahmed, Hind S. Yagoub, Mohamed A. Hassan

  KEYWORDS: Preeclampsia, TMPRSS6 Gene Polymorphism, rs855791SNP

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.1, January 19, 2023

  ABSTRACT: Introduction: Preeclampsia can lead to several maternal and perinatal adverse effects. There are few published data on the association between transmembrane serine protease 6 (TMPRSS6) gene polymorphism and preeclampsia. Objective: To assess the association between TMPRSS6 gene polymorphism rs855791SNP in women with preeclampsia compared with healthy pregnant women. Method: A case-control study (60 women in each arm) was conducted at Saad Abuaela Maternity Hospital in Khartoum, Sudan. Sociodemographic and clinical data were gathered through a questionnaire. The participant was genotype for TMPRSS6 gene rs855791SNP using Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP). The results were confirmed by DNA sequencing. Result: There was no significant difference in the median of age, parity, and body mass index. The distribution of the genotypes and alleles of TMPRSS6 rs855791 was consistent with the HWE. The overall TMPRSS6 rs855791 polymorphism was not significantly associated with preeclampsia. However, the proportion of heterozygotes (TC) was considerably higher in the women with preeclampsia (46.7%) than in the control group (23.3%) (p = 0.001; OR = 2.71; 95% CI = 1.21 - 6.07). The proportion of homozygotes (TT) and T alleles was not significantly different between women with preeclampsia and the control group. Conclusion: The overall TMPRSS6 rs855791 polymorphism was not significantly associated with preeclampsia and healthy control.