TITLE:
Investigating a Vitamin D Delivery Toothpaste Using a Penetration Enhancer Compound
AUTHORS:
Naree Lee, Jongbin Lee
KEYWORDS:
Azone Compound, Drug Delivery System, Intraoral Delivery, Penetration Enhancer, Toothpaste, Vitamin D
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.14 No.1,
January
13,
2023
ABSTRACT: Expanding in the oral care business, being passionately
driven by innovative and scientific products, functional toothpaste has
recently become more popular for functionality, variety, and efficacy. Many new
types of toothpaste are commercially manufactured with diverse fragrances,
colors, probiotics, and pharmaceutical ingredients to enhance the
functionalities of toothpaste. Our study attempted to create a toothpaste
formulation that might facilitate the intraoral delivery of vitamin D3 into the
bloodstream. Simply brushing our teeth with toothpaste should be easy to take
the essential vitamin regularly. In this study, an emulsion-based toothpaste
mixed with an azone compound and sodium dodecyl sulfate as penetration
enhancers blended thoroughly with other ingredients and then with vitamin D. Multiple
toothpaste characteristic tests were performed, such as abrasiveness,
scratchiness, spreadability, pH, foaming, cleaning, and antibacterial strength
with our vitamin D toothpaste, and compared with those of other commercial
brand toothpaste. To confirm the intraoral delivery of vitamin D through the
oral cavity, an earthworm transport study and TEER value test were conducted
using L. terrestris skin. Our data demonstrated the high feasibility of
intraoral delivery of vitamin D based on those two skin studies with various
experimental support; our vitamin D toothpaste had comparable characteristics
with other commercial toothpaste for cleaning functionality.