TITLE:
Darier Ferrand Mammary Dermatofibrosarcoma Simulating a Breast-Type Myofibroblastoma: A Case Report
AUTHORS:
Michel Auguste Mouelle, Sarah Gaëlle Adiang, Esther Meka
KEYWORDS:
Myofibroblastoma, Dermatofibrosarcoma of Darier Ferrand, Breast
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.12 No.1,
January
13,
2023
ABSTRACT: Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare
entities that are similar both in terms of clinical morphological
characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history
of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic
consultation was performed. Clinical examination revealed a firm 25 mm mass on
the medial part of the left breast with skin involvement. A biopsy was
performed and analysis result came back in favor of a cellular type
myofibroblastoma showing a fibrous component consisting of spindle cells with a
herringbone arrangement. Anatomopathological results concluded to a
dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor
population strongly positive for CD34 expression. The search for a
rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in
situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of
Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical
treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of
the lesions with margins greater than 2 cm, on which the prognosis mainly
depends. Micrographic surgery and oncoplastic breast surgery are of major
interest in this location.