TITLE:
Bat 26 Microsatellite Instability in Oral Cavity Cancers in Senegal
AUTHORS:
Mame Diarra Samb, Fatimata Mbaye, Mouhamadou Makhtar Ndiaye, Silly Toure, Mbacke Sembene
KEYWORDS:
Cancer, Oral Cavity, Microsatellite Instability, Bat 26, Senegal
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.1,
January
12,
2023
ABSTRACT: Oral cavity cancers are part of head and neck
cancers. They have become frequent in the world in general and Senegal in
particular. This study evaluates microsatellite instability tumors in oral
cavity cancers in Senegal. Forty cancerous tissues, 20 healthy tissues, and 12
blood tissues were included in this study. These tissues were collected from
each patient during the biopsy after obtaining consent. DNA extraction,
Polymerase Chain Reaction (PCR) and sequencing were carried out to obtain
sequences. Mutation surveyor, Bioedit and Dnasp software were used to perform
our analyses. High instability was found in 57.5% of patients with cancer.
Moreover, 90% of the patients had the same motif on healthy and cancerous
tissue. Furthermore, 26.12%, 20.72%, and 11.71% polymorphic sites were found in
cancerous, healthy and blood tissue respectively. Thus, a similarity between
cancerous and healthy tissues seems to exist. This implies that instability of
the Bat 26 microsatellite could occur early in the occurrence of oral cavity
cancers.