TITLE:
Profiling of Antifungal Activities from the Leaf Extract of Selected Apiaceae Family Plants against Aspergillus fumigates
AUTHORS:
Sakshi Tripathi, Vivek Morya, Veeru Prakash
KEYWORDS:
Antifungal, Aspergillus fumigatus, Ethnobotanical, Fungicidal, Medicine
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.14 No.1,
January
9,
2023
ABSTRACT: Many ethnic plants are used as a source of traditional medicine to cure a
variety of illnesses in both humans and animals. Developing secondary
metabolites in plants with antifungal characteristics, offer alternative
medications for reasonably priced and safe
treatments. In the present study, methanolic, ethanolic, hexane and ethyl acetate leaves extracts
of fifteen Apiaceae family plants were taken on the premise of their
ethno botanical uses. The antifungal activity
was assessed against significant fungal strain; Aspergillus fumigates by measuring minimum inhibitory concentration (MIC) and Zone of inhibition compared with standard drug fluconazole. Ethanol
and methanol extracts of the plants were more effective than the hexane and
ethyl acetate extracts against A.
fumigates. Extracts of Cuminum
cyminum, Pastinca sativa, Carum carvi, Dacus carota, Centella asiatica, Anthriscus cerefolium, Trachyspermum ammi, Pimpenella anisum and Apium graveolens showed
relatively low inhibition effects between 3.5 to 8.5 mm. The MIC value of
extracts was determined ranging between 0.8
to 0.43 μg/ml. The extract of Petroselinum
crispum, Foeniculum vulgare, Ferula
assaefoetida, Bunium persicum,
Anethum graveolens and Coriander
sativum could be considered as potential source of antifungal compounds for treating diseases in humans. Conclude remarks
that these six extracts show astonishing fungicidal properties that can be used
to discover drugs of very high potential.