TITLE:
Advanced Cutaneous Scalp Eccrine Adenocarcinoma, Diagnosis and Treatment Challenges: A Case Report
AUTHORS:
Toky Rakotoarivo, Christian Tomboravo, Malala Razakanaivo, Clairette Raharisolo, Florine Rafaramino
KEYWORDS:
Adenocarcinoma, Eccrine, Chemotherapy, Radiotherapy, Scalp Lesions
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.1,
January
4,
2023
ABSTRACT: In Madagascar, a country with a tropical climate; skin cancers
are often of epidermal or melanic origin. Adnexal tumors are not well known. We report the first case of an eccrine tumor in a 57-year-old
woman with no personal or family history of cancer. She has no comorbidities. The patient presented with a 50 × 60 mm frontal swelling and an ulcerative lesion of
the left half of the face that had been evolving for 5 months. The cerebral and cervical CT scan revealed bone lysis of the vault of the skull
and left cervical lymphadenopathy. The CT chest-abdomen-pelvis showed no
abnormal lesions. The mammogram was normal. The result of the
pathological examination was in favor of a round-cell tumor. The AE1/AE3, CK7 and P63 markers were
positive in the immunohistochemical study. The diagnosis of an advanced eccrine
adenocarcinoma was retained after the
exclusion of a visceral adenocarcinoma with cutaneous metastasis. The patient
receives radiotherapy of 40 Gy in 20 fractions followed by 6 courses of
Carboplatin-paclitaxel type chemotherapy. The lesion has decreased in size and
dried up after
these treatments. 3 months after stopping treatment for lack of financial means, the
patient died at home. The diagnosis of an adnexal tumor requires more in-depth complementary examinations. Treatments should be multidisciplinary and adapted to each
patient.