Article citationsMore>>

Tchuente Tchuenmogne, M.A., Kammalac, T.N., Gohlke, S., Kouipou, R.M.T., Aslan, A., Kuzu, M., Comakli, V., Demirdag, R., Ngouela, S.A., Tsamo, E., Sewald, N., Lenta, B.N. and Boyom, F.F. (2017) Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance. Medicines (Basel), 4, Article No. 6.
https://doi.org/10.3390/medicines4010006

has been cited by the following article:

• TITLE: Biotolerance Study of the Hydroalcoholic Extract of Terminalia mantaly H. Perrier on Rat Renal Activity

  AUTHORS: Kamo Irié Lou Bohila Emilie, Tra Bi Irie Otis, Kouassi Kouakou Serge, Djaman Allico Joseph, N’guessan Jean David

  KEYWORDS: Terminalia mantaly, Biotolerance, Biochemical Markers

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.10 No.12, December 27, 2022

  ABSTRACT: Terminalia mantaly H. Perrier is one of the plants of the Combretaceae family that is widely used in traditional African medicine for its antibacterial, antifungal, and especially in the treatment of malaria. In this study, we evaluated the effect of the hydroalcoholic extract of Terminalia mantaly (HAETM) on the tissue and kidney biochemical markers of rats. Forty (40) rats were randomly divided into 4 groups, assigning 10 animals within each group (5 males and 5 females per group). Animals in group 1 received distilled water and were used as the control group; on the other hand, groups 2, 3, 4 received by gavage a volume of the extract corresponding to 1 ml/100g body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The hydroalcoholic extract was administered at the same time daily for 28 days, and blood was collected once a week to evaluate renal biochemical parameters; the kidney tissues were used to perform the histopathological study. The creatinine rate increased significantly (p Terminalia mantaly should be globally well tolerated by the body when used in doses ranging from 150 to 600 mg/kg of the body weight in animals (for this study, rats). However, further in-depth studies would be needed to get a more thorough and complete picture of the safety profile of the extract.