TITLE:
The Role of Autophagy in Acute Myeloid Leukemia
AUTHORS:
Siyu Zhou, Yu Wu, Yili Cai, Zecheng Yu, Ruirui Li, Chunwei Yan, Fangwei Dai, Wei Han
KEYWORDS:
Autophagy, Acute Myeloid Leukemia, Signaling Pathway, Clinical Treatment
JOURNAL NAME:
Open Access Library Journal,
Vol.9 No.12,
December
23,
2022
ABSTRACT: Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a potential target for monitoring, prognosis, and molecular diagnosis of leukemia patients. The study summarized the interaction between AML and autophagy-related signal pathways (such as mTOR and PI3K pathway) and explained the influence of related inhibitors and activators on AML cells in recent years, which laid a theoretical foundation for clinical treatment and research development of AML patients.