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Wang, J., et al. (2015) TRPC6 Specifically Interacts with APP to Inhibit Its Cleavage by γ-Secretase and Reduce Aβ Production. Nature Communications, 6, Article No. 8876.
https://doi.org/10.1038/ncomms9876

has been cited by the following article:

• TITLE: The CircRNAs for Diagnostic, Prognostic, and Therapy in Alzheimer’s Disease

  AUTHORS: Erika Alejandra Cabrera-Reyes, Miguel Alejandro Jiménez-Acosta, Mayte Lizeth Padilla-Cristerna, Marco Antonio Meraz-Ríos

  KEYWORDS: CircRNA, Alzheimer’s Disease, miRNAs, Diagnosis, Therapy, Dementia

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.13 No.12, December 21, 2022

  ABSTRACT: The structure and biological function of circular RNAs (circRNAs) in regulating gene expression in a cell is far from known. CircRNAs are unique molecules that contain potent regulatory elements. CircRNAs actively interact with miRNAs (sponging), affecting their regulation and functions. In addition, circRNAs have roles in transcriptional regulation, splicing, and peptide synthesis. With all these properties, circRNAs could play an essential role in diseases, especially Alzheimer’s. Their role in early diagnosis, previous to present symptoms, prognosis associated with neuropathological AD of specific circRNAs, and one of their primary functions is to act as a sponge for miRNAs, which could be a starting point for future gene therapy. This review aims to summarize the current knowledge of these exciting molecules and their potential use as new markers for AD risk. This article will focus on circRNAs deregulated in Alzheimer’s.