TITLE:
Chronic Lymphocytic Leukemia of del 17p in a Young Subject: About a Case and Reviewed a Literature
AUTHORS:
Amadou Djibrilla-Almoustapha, Moustapha Mamane-Brah, Moustapha Elhadj-Chefou, Maman Rabiou Badé, Faiza Abba-Ousmane, Fanta Ousseini, Oumoulkairou Abdoulaye-Soumana, Badé Malam-Abdou
KEYWORDS:
Chronic Lymphocytic Leukemia, Young Subject, del 17 p, HNN, Niger
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.12 No.4,
December
12,
2022
ABSTRACT: Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young
subject, with variable clinical features and a TP53 mutation, diagnosed and
followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia,
whose clinical examination found a conscious patient, submaxillary,
laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical,
painless and non-compressive whose largest measures 3 cm in diameter.
Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis,
immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid
proliferation. The Matutes score was 4. A karyotype showed a three-chromosome
translocation; the short arm of a chromosome 2, the long arm of a chromosome 11 and the long
arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH
objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was
retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol
was instituted with once-weekly transfusions. The patient is still alive in
partial clinical and biological remission. Conclusion: Despite
therapeutic progress, the presence of the deletion of chromosome 17p with TP53
mutation and the young age of the patient does not change the patient’s
prognosis.