TITLE:
IgG Anti-Body Titers among Patients with Amoebic Liver Abscess in Bangui, Central African Republic
AUTHORS:
Wilfrid Sylvain Nambei, Edwige Régina Kodia-Lenguetama, Junior Nguerenam-Ouefio
KEYWORDS:
Amoebic Liver Abscess, Antibody, Sex Difference, Central African Republic
JOURNAL NAME:
Open Journal of Immunology,
Vol.12 No.4,
December
9,
2022
ABSTRACT: Entamoeba histolytica (Eh) is a protozoan parasite that causes amoebiasis characterized by
intestinal damage and amoebic liver development and is an important cause of hospitalization in low-middle income
countries. The aims of this study were to determine the prevalence and the titer of IgG anti Eh in ALA (Amoebic Liver Abscess)
patients’ in Bangui according sex, age and other risk factors. This was a cross
sectional study where data was collected between January 2018 and October 2020.
The diagnosis of ALA was suspected based on clinical symptoms of; fever,
abdominal pain (usually in the right hypochondrium or epigastrium) and clinical
signs of hepatomegaly and/or tender liver with or without jaundice and
abdominal ultra-sonography. ALA patients’ IgG antibody titers were
measured by Indirect Hemmaglutination Assay and Chi-square test was used. A total of 1249 ALA
patients were included, among whom 570 (45.64%) were positive. Of these, 244
(42.08%) had titer 1:160 or less, 223 patients’ (39.13%) had titer ranging from
1:320 to 1:640 and 103 patients (18.07%) had strong titer ranging from 1:1280
to 1:2560. The association between antibody titer results, age and sex was no
significant (p = 1.0000). Our findings indicate a high prevalence of ALA and
show no significant difference between the sex and age ALA patients.